Sr. Research Investigator/Principal Investigator- Computational Antibody Discovery

Company: Incyte Corporation
Location: Wilmington
Posted on: February 12, 2025

Job Description:

Overview

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules. Job Summary (Primary function)The successful applicant will assume an integral role leading in silico antibody discovery strategies in support of Incyte's pre-clinical biotherapeutic portfolio. The ideal candidate will hold deep subject matter expertise within antibody biology and/or antibody engineering, possess hands on experience in leveraging protein language models, inverse folding algorithms and molecular modelling tools (e.g., Rosetta) to guide in silico antibody discovery and optimization. The candidate will assume a central role within the Antibody Discovery team where they will work to augment existing in vitro and in vivo antibody discovery workflows with in silico strategies, while contributing to the development of a broader AI-powered discovery pipeline at Incyte. They should work well in a highly collaborative and interdisciplinary atmosphere, leverage internal resources to accomplish objectives under accelerated timelines, and independently contribute to both the technological and intellectual development of the antibody discovery pipeline. They will be expected to maintain detailed electronic laboratory notebook records of ongoing activities and present their findings regularly in a group setting. Job Responsibilities

• Contribute to the identification and optimization of lead compounds by leveraging artificial intelligence and/or machine learning strategies for in silico sequence design and optimization
• Manage Rosetta-based molecular modeling projects to support lead molecule refinement
• Proactively identify and deploy open-source models and develop in-house ML based models to facilitate Antibody discovery and optimization.
  • Leverage next-generation antibody sequencing data together with wet-lab experimental data to empower in silico sequence design
    • Maintain detailed and up-to-date electronic lab notebook
      • Data analysis and presentation to program teams
        • Work collaboratively under aggressive timelines Minimum Requirements
          • PhD with 1-3 years' of relevant experience, industry experience preferred
            • Strong background in antibody biology/engineering and/or B cell immunology
            • Strong computational background with experience in programming languages such as Python, R etc.
              • Proficient in the application of in silico methods for antibody discovery and sequence optimization
                • Proficient in identifying deploying ML based models to leverage in house experimental data to support Antibody discovery programs.
                • Hands on experience in single B cell screening technologies preferred.
                  • Experience with next-generation sequencing approaches and antibody sequence analysis a plus Excellent organization and communication skills Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.We Respect Your PrivacyLearn more at: The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.
                    
                    During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process .You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work. You can learn more about Incyte's data protection practices . By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable).Please contact privacy@incyte.com if you have any questions or concerns or would like to exercise your rights.Required
                    Preferred

                    Job Industries

                    • Other

Keywords: Incyte Corporation, Wilmington , Sr. Research Investigator/Principal Investigator- Computational Antibody Discovery, Other , Wilmington, Delaware